"UNDER THE WEATHER-PRESSURE."
From quite early in my experience of the disorderknown as "Paraproteinaemic Demyelinating Neuropathy" or MGUS-related neuropathy, I noticed a link between many very painful relapses and sharp falls in ambient (surrounding) atmospheric pressure. The disorder is very similar to Chronic CIDP, which in turn is related to the acute Guillain-Barré Syndrome. In these disorders the myelin sheath protection of peripheral nerve cells is damaged, causing a nerve disorder or neuropathy, Sometimes the central core of the nerves, the axon, is also damaged. In the case of "my" paraproteinaemic demyelinating neuropathy, IgA, there is some motor nerve damage, but not severe functional impairment, However there is axonal damage and much more sensory nerve loss, the sensory nerve conduction being more abnormal. So there is constant pain, which becomes very severe in the relapses.
These relapses always feature the onset of more severe painand strong tightening of the muscles in my feet and into my legs, neuro-muscular change. It is often accompanied by considerable tiredness. The fall in pressure is indicated on our Spout or Water Barometer, the oldest type of barometer known to mankind, The atmospheric pressure acts on the surface of the water and causes the level in the bottle to rise during higher pressure and to fall in step with the pressure's fall, As the water level falls in the bottle the water rises up the spout and then drips out during deeper falls in the pressure. Although it is ungraduated, the water barometer is reliable and consistent. Its' movements are even finer than those on our mercury barometer.
So the rise and falls of the water barometer's levels indicate, on a large scale, the fluctuations of the small changes of pressure caused by the local micro-climate, even though there may be a "high" or a "low" pressure system overall.
Usually the start of the relapse,with the accompanying increase in pain, precedes any indication on the water's surface! As for scientific assessment it must be said that the relationship between crisis relapses and falls in pressure is invariable in my experience. The relapses are different to "normal" relapses and appear to be enforced by the conditions. So it seems that I have barometric feet and legs! The pain begins before the shift in the pressure and any weather chanqe, no matter how small. This is just the same as the majority of Jamison's questionnaire patients who reported that their aggravation began before weather shifts. He reported, "This leads me to conclude that changes in barometric pressure are the main link between weather and pain,"
Some other inflammatory disorder sufferersknown to me also suffer crises and have various indicators of pressure falls. "Expert" opinion has suggested that some sufferers may have heightened awareness of and sensitivity to pain. There is more to it than this explanation. There is muscular change and increase in pain; this is no old wives' tale! Confirmation has come from the experience of resident and her mother in California's San Francisco Bay area. See "Under the Weather-Pressure. Part 2 " My conjecture as to the possible reason for my relapses, as the atmospheric pressure falls, is described on another web site of mine, "Paraproteinaemic Demyelinating Neuropathy". www.pdn-info.co.uk My guess/conjecture may be as good as anyone else's!
For a useful pain scalevisit